Few studies of PKR’s role in naturally occurring cancers have been conducted, and these reports are equivocal with respect to a tumor suppressor function. In murine lymphoblastic leukemic cells (Jaramillo et al., 1995) and some human leukemic and preleukemic myeloid cells (Beretta et al. cheap mlb Jerseys, 1996) PKR expression is higher than in the corresponding normal cells as would be expected if PKR were functioning as a tumor suppressor. The observation that PKR levels in head and neck squamous carcinomas are inversely proportional to that of PCNA, may lend support to PKR being anti proliferative (Haines et al., 1998).
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